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Database is Updated at 09/10/07; Release 6.0 Contents �悭���鎿��iFAQ) �p��̂� About the Database Keyword Search BLAST Search Genome Browser Statistics Material and Methods Human-Macaque Citation Data download FAQ Links JCRB Genebank HSRRB National Institute of Biomedical Innovation H-Inv DB PRIGEN �J�j�N�C�U��cDNA�f�[�^�x�[�X�ɂ‚��� QFbase�i�J�j�N�C�U��cDNA�f�[�^�x�[�X�j��JCRB��`�q�o���N���Ɨ��@�l����Ռ���������ь����J���Ȍ����Ȋw������̃T�|�[�g�ɂ���ĉ^�c���Ă��܂��B ���f�[�^�x�[�X�̓J�j�N�C�U�� (Macaca fascicularis) �̔]�A�����A�̑��A�����C�B���C�X���C�t���C�S���C���B�R���̃I���S�L���b�s���OcDNA���C�u�����[�̏���񋟂��Ă��܂��B �J�j�N�C�U���̓}�J�N���̃T���ŁA�����w�A�s���w�A�򗝊w�A��w�������ɗp�����A���������Ƃ��ėp�����Ă���ł��|�s�����[�ȃT���̈�‚ł��B���������ł͂����̌����ɗL�p�ȃQ�m�����A��`�q�����̊�Ր�����ړI�Ƃ��āA�I���S�L���b�s���O�@�ɂ���č쐻���ꂽcDNA���C�u�����[�̍쐻�A��́A�ۑ����s���Ă��܂��B ��120,000��5'���[�z�� (5'-EST) �A��22,000��3'���[�z��A��9,600�̑S��cDNA�z�񂪌��ݓo�^����Ă��܂��B�z��̓q�g�W����`�q (RefSeq) �z��Ƃ̃z�����W�[�ɂ���Đ�������Ă��܂��B���݁A�q�g��`�q������̌����܂���BLAST�T�[�`�ɂ��z�����W�[�����ɂ��A�ړI�̃N���[����T�����Ƃ��o���܂��B���̃��j���[����Keyword Search�܂���BLAST Search��I��ł��������B ������cDNA�N���[���̓q���[�}���T�C�G���X���������o���N (HSRRB) ��ʂ��č����O�̌����҂ɋ�������Ă��܂��B�i�ڂ�����HSRRB�̃E�F�u�T�C�g�������������j ��) �̑��R���N���[���ɂ‚��Ă�QlvC�Ŏn�܂�N���[���̂ݕ������s���Ă���܂��B�ڂ�����JCRB��`�q�o���N�܂ł��₢���킹���������B �X�ɓ��T�C�g�ł͗쒷�ނ̐i����͂̃��\�[�X�Ƃ���4004��`�q�̃q�g-�J�j�N�C�U���A���C�������g�����J���Ă��܂��B��`�q���Ƃɔ񓯋`�u����(Ka)�A���`�u����(Ks)���v�Z����Ă���A�i�����x��������`�q���������邱�Ƃ��o���܂��B �܂��C�J�j�N�C�U����cDNA�N���[���CBAC�N���[���C�}�C�N���T�e���C�g�}�[�J�[���A�J�Q�U���Q�m����Ƀ}�b�s���O�����Q�m���u���E�U�������ɂȂ�܂��D ����E�A���� ���̃T�C�g�͓Ɨ��s���@�l����Ռ������C���c���C���c�����ɂ���č쐬����܂����D ���c���� �Ɨ��@�l����Ռ����� ��a�E�������������� ��a������������ �Q�l���� �J�j�N�C�U��cDNA�v���W�F�N�g�Ɋւ���_�� Naoki Osada, Makoto Hirata, Reiko Tanuma, Yutaka Suzuki, Sumio Sugano, Keiji Terao, Jun Kusuda, Yosuke Kameoka, Katsuyuki Hashimoto, Ichiro Takahashi. Collection of Macaca fascicularis cDNAs derived from bone marrow, kidney, liver, pancreas, spleen, and thymus. BMC Res. Notes 2: 199 (2009) [Link]. Higashino A, Osada N, Suto Y, Hirata M, Kameoka Y, Takahashi I, Terao K. Development of an integrative database with 499 novel microsatellite markers for Macaca fascicularis. BMC Genetics 10: 24 (2009) [Link]. Naoki Osada, Katsuyuki Hashimoto, Yosuke Kameoka, Makoto Hirata, Reiko Tanuma, Yasuhiro Uno, Itsuro Inoue, Munetomo Hida, Yutaka Suzuki, Sumio Sugano, Keiji Terao, Jun Kusuda, Ichiro Takahashi. Large-scale analysis of Macaca fascicularis transcripts and determination of genetic divergence between M. fascicularis and M. mulatta. 2008 BMC Genomics 9: 90 [Link]. Hurng-Yi Wang, Huan-Chieh Chien, Naoki Osada, Katsuyuki Hashimoto, Sumio Sugano, Takashi Gojobori, Chen-Kung Chou, Shih-Feng Tsai, Chung-I Wu, C.-K. James Shen. Rate of evolution of brain-expressed genes in humans and other primates. 2006. PLoS Biol. 5: e13. [Link] Osada, N., M. Hirata, R. Tanuma, J. Kusuda, M. Hida, Y. Suzuki, S. Sugano, T. Gojobori, C.K. Shen, C.I. Wu, and K. Hashimoto. Substitution Rate and Structural Divergence of 5'UTR Evolution: Comparative Analysis Between Human and Cynomolgus Monkey cDNAs. 2005. Mol. Biol. Evol. 22: 1976-1982. [Link] Imanishi, T., Itoh, T., Suzuki, Y., O'Donovan, C., Fukuchi, S., Koyanagi, K.O., Barrero, R.A., Tamura, T., Yamaguchi Kabata, Y., and Tanino, M. et al 2004. Integrative annotation of 21,037 human genes validated by full-length cDNA clones. PLoS Biol 2: e162. [Link] Osada, N., Kusuda, J., Hirata, M., Tanuma, R., Hida, M., Sugano, S., Hirai, M., and Hashimoto, K. 2002. Search for genes positively selected during primate evolution by 5'-end-sequence screening of cynomolgus monkey cDNAs. Genomics 79: 657-662. [Link] Osada, N., Hida, M., Kusuda, J., Tanuma, R., Hirata, M., Suto, Y., Hirai, M., Terao, K., Sugano, S., and Hashimoto, K. 2002. Cynomolgus monkey testicular cDNAs for discovery of novel human genes in the human genome sequence. BMC Genomics 3: 36. [Link] Osada, N., Hida, M., Kusuda, J., Tanuma, R., Hirata, M., Hirai, M., Terao, K., Suzuki, Y., Sugano, S., and Hashimoto, K. 2002. Prediction of unidentified human genes on the basis of sequence similarity to novel cDNAs from cynomolgus monkey brain. Genome Biol 3: RESEARCH0006. [Link] Osada, N., Hida, M., Kusuda, J., Tanuma, R., Iseki, K., Hirata, M., Suto, Y., Hirai, M., Terao, K., and Suzuki, Y. et al 2001. Assignment of 118 novel cDNAs of cynomolgus monkey brain to human chromosomes. Gene 275: 31-37. [Link] Hida, M., Suzuki, Y., Sugano, S., Hashimoto, K., Terao, K., Hayasaka, I., Hirai, M. 2000 Construction and preliminary characterization of full length enriched cDNA libraries for nonhuman primates. Primate Research (Japanese) 16: 95-110. [Link] ���@ Kato, S. et al. 2005. Vector-capping: a simple method for preparing a high-quality Full-Length cDNA Library. DNA Res. 12:53-62. Jurka J 2000. Repbase update: a database and an electronic journal of repetitive elements. Trends Genet 16: 418-420. Suzuki, Y., Yoshitomo Nakagawa, K., Maruyama, K., Suyama, A., and Sugano, S. 1997. Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. Gene 200: 149-156. Thompson, J.D., Higgins, D.G., and Gibson, T.J. 1994. CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res 22: 4673-4680. Li WH 1993. Unbiased estimation of the rates of synonymous and nonsynonymous substitution. J Mol Evol 36: 96-99. Pamilo P, Bianchi NO 1993. Evolution of the Zfx and Zfy genes: rates and interdependence between the genes. Mol Biol Evol 10: 271-281.

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